Round 5
|
| Wednesday, 3 September 2008 |
| Libertad | 4 | Sportivo Luqueño | 2 |
| 6 Gamarra | | 31 Fernández | |
| 64 Gamarra | | 87 Sanabria | |
| 66 Maciel | | | |
| 69 Martínez | | | |
| Olimpia | 0 | Guaraní | 2 |
| | | 66 Benitez | |
| | | 72(p) Fabbro | |
Round 7
|
| Sunday, 7 September 2008 |
| Olimpia | 2 | Sportivo Luqueño | 1 |
| 5(p) Lazaga | | 20 Vargas | |
| 61 Lazaga | | | |
Round 8
|
| Saturday, 13 September 2008 |
| Tacuary | 0 | 12 de Octubre | 1 |
| | | 85 Pacielo | |
| Guaraní | 0 | Sol de América | 0 |
| Sunday, 14 September 2008 |
| Cerro Porteño | 2 | Nacional | 3 |
| 4 Avalos | | 20 Espínola | |
| 41 Servin | | 42 Arriola | |
| | | 63 Ramos | |
| Libertad | 1 | Olimpia | 1 |
| 4 Gamarra | | 63 Lucero | |
| Sportivo Luqueño | 1 | 2 de Mayo | 1 |
| 76(p) Vargas | | 78 Cano | |
| 3 de Febrero | 2 | Silvio Pettirossi | 0 |
| 3 Cazal | | | |
| 48 Cazal | | | |
Round 9
|
| Friday, 19 September 2008 |
| 2 de Mayo | 1 | Libertad | 1 |
| 81 Figueredo | | 77 Samudio | |
| Sol de América | 1 | Cerro Porteño | 2 |
| 55 Benítez | | 51(p) Cabrera | |
| | | 73 Gamarra | |
| Silvio Pettirossi | 0 | Guaraní | 1 |
| | | 60 Fabbro | |
| Saturday, 20 September 2008 |
| 12 de Octubre | 2 | 3 de Febrero | 1 |
| 3 Notario | | 34 Mencia | |
| 36 Núñez | | | |
| Nacional | 0 | Sportivo Luqueño | 0 |
| Sunday, 21 September 2008 |
| Olimpia | 1 | Tacuary | 3 |
| 58 Lazaga | | 27 Ferreira | |
| | | 84 Ruiz | |
| | | 88(p) Sanabria | |
Round 10
|
| Tuesday, 23 September 2008 |
| Cerro Porteño | 1 | Silvio Pettirossi | 1 |
| 68 Giménez | | 4 Bareiro | |
| Wednesday, 24 September 2008 |
| Olimpia | 3 | 12 de Octubre | 1 |
| 25(p) Lazaga | | 21 Notario | |
| 68 Rojas | | | |
| 75 González | | | |
| Libertad | 3 | Nacional | 0 |
| 37 Olivera | | | |
| 73 Alvarez | | | |
| 88 Samudio | | | |
| Guaraní | 2 | 3 de Febrero | 1 |
| 65 Gonzalez | | 88 Leite | |
| 81 Fabbro | | | |
| Tacuary | 1 | 2 de Mayo | 2 |
| 33 Giménez | | 13 Cano | |
| | | 26 Figueredo | |
| Sportivo Luqueño | 0 | Sol de América | 3 |
| | | 55 Pereira | |
| | | 67 Benítez | |
| | | 69 Ortigoza | |
Round 11
|
| Saturday, 27 September 2008 |
| 3 de Febrero | 1 | Cerro Porteño | 1 |
| 25 Benitez | | 89 Avalos | |
| Sunday, 28 September 2008 |
| 2 de Mayo | 1 | Olimpia | 1 |
| 30 Almada | | 85 Caballero | |
| Sol de América | 0 | Libertad | 1 |
| | | 45 Samudio | |
| Nacional | 1 | Tacuary | 0 |
| 63(p) Ramos | | | |
| 12 de Octubre | 4 | Guaraní | 1 |
| 23 Martínez | | 60 Caceres Cañete | |
| 27(p) Esteche | | | |
| 45 Beltran | | | |
| 89 Beltran | | | |
| Silvio Pettirossi | 0 | Sportivo Luqueño | 0 |
Primera División 2008