Round 25
|
| Thursday, 4 September 2008 |
| Portland Timbers | 4 | Miami FC Blues | 0 |
| 3 Alvarez | | | |
| 41 Dunn | | | |
| 48 Brown | | | |
| 70 Brown | | | |
Round 24
|
| Friday, 5 September 2008 |
| Puerto Rico Islanders | 1 | Vancouver Whitecaps | 0 |
| 89 Delgado | | | |
Round 25
|
| Montreal Impact | 1 | Minnesota Thunder | 1 |
| 45(p) Grande | | 21 Deroux | |
| Saturday, 6 September 2008 |
| Rochester Raging Rhinos | 2 | Portland Timbers | 0 |
| 40 Delicâte | | | |
| 87 Heins | | | |
| Carolina RailHawks | 3 | Charleston Battery | 1 |
| 21(p) Low | | 68 King | |
| 43 Curfman | | | |
| 86 Martinez | | | |
| Seattle Sounders | 3 | Miami FC Blues | 0 |
| 33(p) O'Brien | | | |
| 60 Le Toux | | | |
| 77 O'Brien | | | |
| Sunday, 7 September 2008 |
| Vancouver Whitecaps | 0 | Minnesota Thunder | 0 |
Round 23
|
| Monday, 8 September 2008 |
| Montreal Impact | 2 | Portland Timbers | 0 |
| 13 Di Lorenzo | | | |
| 45 Byers | | | |
Round 26
|
| Wednesday, 10 September 2008 |
| Seattle Sounders | 1 | Montreal Impact | 2 |
| 62 Kanté | | 59 Donatelli | |
| | | 70 Ribeiro | |
| Thursday, 11 September 2008 |
| Portland Timbers | 1 | Charleston Battery | 2 |
| 14 Higgins | | 73 Alavanja | |
| | | 89 King | |
| Friday, 12 September 2008 |
| Rochester Raging Rhinos | 0 | Puerto Rico Islanders | 2 |
| | | 10 Jagdeosingh | |
| | | 53 Arrieta | |
| Saturday, 13 September 2008 |
| Minnesota Thunder | 4 | Charleston Battery | 0 |
| 44 Knox | | | |
| 49 Tarley | | | |
| 83 Tarley | | | |
| 89 Fred | | | |
| Vancouver Whitecaps | 1 | Montreal Impact | 0 |
| 45 Gbeke | | | |
| Seattle Sounders | 1 | Atlanta Silverbacks | 1 |
| 38 Le Toux | | 56 Kandji | |
Round 27
|
| Sunday, 14 September 2008 |
| Carolina RailHawks | 1 | Rochester Raging Rhinos | 1 |
| 7 Diallo | | 82 Smith | |
Round 22
|
| Wednesday, 17 September 2008 |
| Miami FC Blues | 1 | Rochester Raging Rhinos | 0 |
| 72 Alex Afonso | | | |
Round 29
|
| Friday, 19 September 2008 |
| Charleston Battery | 1 | Carolina RailHawks | 2 |
| 65 Richardson | | 8 Diallo | |
| | | 24 Diallo | |
Round 30
|
| Puerto Rico Islanders | 1 | Atlanta Silverbacks | 1 |
| 61 Arrieta | | 55 McLaughlin | |
| Saturday, 20 September 2008 |
| Minnesota Thunder | 3 | Montreal Impact | 1 |
| 38 Sánchez | | 32 Surprenant | |
| 60 Cvilikas | | | |
| 70 Bass | | | |
| Seattle Sounders | 2 | Vancouver Whitecaps | 3 |
| 10 Le Toux | | 54 Sebrango | |
| 69 Sakuda | | 57 Moose | |
| | | 67 Clarke | |
| Carolina RailHawks | 1 | Portland Timbers | 0 |
| 90 Nuńez | | | |
Round 27
|
| Sunday, 21 September 2008 |
| Montreal Impact | 0 | Puerto Rico Islanders | 0 |
Round 30
|
| Miami FC Blues | 1 | Atlanta Silverbacks | 0 |
| 53 Fraser | | | |
Round 0l1
|
| Friday, 26 September 2008 |
| Seattle Sounders | 2 | Montreal Impact | 1 |
| 15 Alcaraz-Cuellar | | 21 Pesoli | |
| 42 O'Brien | | | |
| Rochester Raging Rhinos | 2 | Charleston Battery | 0 |
| 86 Guppy | | | |
| 90 Delicâte | | | |
| Vancouver Whitecaps | 2 | Minnesota Thunder | 0 |
| 27(og) Greenfield | | | |
| 89 Moose | | | |
Round 0l2
|
| Sunday, 28 September 2008 |
| Montreal Impact | 3 | Seattle Sounders | 1 |
| 56 Testo | | 59 Levesque | |
| 75 Placentino | | | |
| 90 Ribeiro | | | |
| Charleston Battery | 1 | Rochester Raging Rhinos | 0 |
| 12 Alonso | | | |
| Minnesota Thunder | 4 | Vancouver Whitecaps | 3 |
| 23 Gonzalez | | 3 Valente | |
| 64 Tarley | | 44 Nash | |
| 78 Deroux | | 55 Sebrango | |
| 90(p) Fred | | | |
USL-1 2008