| Player | First | Overall | Last |
| Cooper (FC Dallas) | 6 | (1) | 16 | (3) | 5 | (1) |
| Barrett (Chicago Fire/Toronto FC) | 6 | | 9 | | 1 | |
| Twellman (N.E. Revolution) | 5 | | 7 | | 1 | |
| Ching (Houston Dynamo) | 4 | | 12 | | 4 | |
| Emilio (D.C. United) | 4 | | 11 | | 5 | |
| Alvarez (FC Dallas/San Jose) | 4 | | 6 | | 1 | |
| Rolfe (Chicago Fire) | 4 | | 6 | | 1 | |
| Dichio (Toronto FC) | 4 | | 5 | | 0 | |
| Moreno (D.C. United) | 3 | (2) | 10 | (4) | 2 | |
| Barros Schelotto (Columbus Crew) | 3 | (2) | 6 | (4) | 0 | |
| Donovan (L.A. Galaxy) | 3 | | 19 | (3) | 4 | |
| Ángel (New York) | 3 | | 11 | (1) | 3 | |
| Moreno (Columbus Crew) | 3 | | 9 | | 2 | |
| Ralston (N.E. Revolution) | 3 | | 8 | (1) | 1 | |
| Cunningham (Toronto FC/FC Dallas) | 3 | | 8 | | 3 | |
| Morales (Real Salt Lake) | 3 | | 6 | | 1 | |
| Cristman (N.E. Revolution) | 3 | | 6 | | 0 | |
| Conrad (K.C. Wizards) | 3 | | 5 | | 1 | |
| Johnson (San Jose) | 3 | | 5 | | 1 | |
| Espindola (Real Salt Lake) | 3 | | 5 | | 1 | |
| Eskandarian (Chivas USA) | 3 | | 5 | | 1 | |
| Movsisyan (Real Salt Lake) | 3 | | 5 | | 0 | |
| O'Brien (San Jose) | 3 | | 4 | | 1 | |
| Marshall (Columbus Crew) | 3 | | 4 | | 0 | |
| Davis (Houston Dynamo) | 3 | | 3 | | 0 | |
| Magee (New York) | 2 | (1) | 5 | (1) | 1 | |
| Jewsbury (K.C. Wizards) | 2 | (1) | 3 | (2) | 0 | |
| Casey (Colorado Rapids) | 2 | | 9 | (1) | 4 | |
| Cummings (Colorado Rapids) | 2 | | 6 | | 2 | |
| Van Den Bergh (New York) | 2 | | 6 | | 2 | |
| De Rosario (Houston Dynamo) | 2 | | 5 | (1) | 2 | (1) |
Major League 2008